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Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 533-541 doi: 10.1007/s11684-020-0786-5

Abstract: In addition to major respiratory distress, characteristic neurological manifestations are also described

Keywords： coronavirus disease 2019 (COVID-19)     SARS-CoV-2     neurological manifestations     neuroinvasion     brain    

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Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 651-658 doi: 10.1007/s11684-021-0859-0

Abstract: The patients’ main manifestations were compared.

Keywords： acute coronary syndrome (ACS)     throat discomfort (TD)     throat pain     cardiology departments     non-cardiologic physicians    

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Clinical manifestations and outcomes in severe ulcerative colitis

YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 192-195 doi: 10.1007/s11684-007-0036-0

Abstract: In order to evaluate the clinical manifestations and outcomes of severe ulcerative colitis (UC), we retrospectively
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The development and benefits of metformin in various diseases

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 388-431 doi: 10.1007/s11684-023-0998-6

Abstract: types of diseases, including metabolic associated diseases, cancer, aging and age-related diseases, neurological

Keywords： metformin     metabolism     cancer     aging     neurological disorder    

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Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 86-93 doi: 10.1007/s11684-011-0118-x

Abstract:

Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.

Keywords： adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

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Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19

Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 776-785 doi: 10.1007/s11684-020-0820-7

Abstract: Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread around the world. However, approaches to distinguish COVID-19 from pneumonia caused by other pathogens have not yet been reported. We retrospectively analyzed the clinical data of 97 children with probable COVID-19. A total of 13 (13.4%) patients were confirmed positive for SARS-CoV-2 infection by nucleic acid RT-PCR testing, and 41 (42.3%) patients were found to be infected with other pathogens. Notably, no pathogen was detected in 43 (44.3%) patients. Among all patients, 25 (25.8%) had familial cluster exposure history, and 52 (53.6%) had one or more coexisting conditions. Fifteen (15.5%) patients were admitted or transferred to the PICU. In the 11 confirmed COVID-19 cases, 5 (45.5%) and 7 (63.6%) were positive for IgM and IgG against SARS-CoV-2, respectively. In 22 patients with suspected COVID-19, 1 (4.5%) was positive for IgG but negative for IgM. The most frequently detected pathogen was (29, 29.9%). One patient with confirmed COVID 19 died. Our results strongly indicated that the detection of asymptomatic COVID 19 or coexisting conditions must be strengthened in pediatric patients. These cases may be difficult to diagnose as COVID-19 unless etiologic analysis is conducted. A serologic test can be a useful adjunctive diagnostic tool in cases where SARS-CoV-2 infection is highly suspected but the nucleic acid test is negative.

Keywords： coronavirus disease 2019     pediatrics     emergency     retrospective investigation     severe acute respiratory syndrome coronavirus 2    

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Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders Review

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Engineering 2020, Volume 6, Issue 4,   Pages 415-423 doi: 10.1016/j.eng.2019.07.026

Abstract: the gut microbiota and the brain via the gut–brain axis, and on the onset and development of neurologicalrelative infancy, clarifying the molecular mechanism that underlies how the gut microbiota regulates neurologicalfunctions not only holds the promise of revealing potentially novel pathogeneses of neurological disordersdevelopment of potential diagnosis biomarkers and intervention strategies targeting microbiota dysbiosis for neurological

Keywords： Gut microbiota     Gut–brain axis     Neurological disorders     Intervention strategies    

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Engineering for Inclusion: Empowering Individuals with Physical and Neurological Differences through

Peter T. Cummings, Philippe M. Fauchet, Michael Goldfarb, Martha W.M. Jones, Maithilee Kunda, Jonathan B. Perlin, Nilanjan Sarkar, Keivan G. Stassun, Zachary E. Warren, Karl E. Zelik

Engineering 2021, Volume 7, Issue 2,   Pages 141-143 doi: 10.1016/j.eng.2020.06.020

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Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

Journal Article

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Journal Article

Clinical manifestations and outcomes in severe ulcerative colitis

YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin

Journal Article

The development and benefits of metformin in various diseases

Journal Article

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Journal Article

Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19

Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li

Journal Article

Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Journal Article

Engineering for Inclusion: Empowering Individuals with Physical and Neurological Differences through

Peter T. Cummings, Philippe M. Fauchet, Michael Goldfarb, Martha W.M. Jones, Maithilee Kunda, Jonathan B. Perlin, Nilanjan Sarkar, Keivan G. Stassun, Zachary E. Warren, Karl E. Zelik

Journal Article